Development of an in vivo method to better understand the obese skin
Development of an in vivo method to better understand the obese skin
Jornal de Investigação Biomédica e Biofarmacêutica
The impact of obesity in the pathophysiology of human skin seems to be related to various dermatoses, basically resulting from the change in its normal physiology, including changes in the “barrier” and the “envelope" functions as well . However, the available information is still scarce due to the many complexities of the subject. This work aims to define an experimental methodology approach to objectively study the functional changes that characterize the obese skin. This transversal study included 28 healthy volunteers, female (mean age 23 ± 5 years old), after informed consent. Skin functional characterization was obtained in one single measurement by non-invasive techniques, under controlled conditions. Relevant variables were hydration (superficial and deep), barrier function and biomechanical behavior, measured at four different anatomical areas. Through the SPSS (v 20.0) a univariate statistical analysis was performed to calculate central tendency and dispersion measures. The Pearson's and the Spearman's tests were chosen for those variables that followed , or not, a normal distribution, respectively, assuming a confidence level of 95%. Results allow us to propose a methodology for the study of the skin applied to obese patients, including the choice of the anatomical areas and variables appropriate to the intended goal.
O impacto da obesidade na fisiopatologia da pele humana parece relacionar-se com diversas dermatoses, resultado da alteração da sua fisiologia normal, incluindo alterações na função barreira e na função de “envelope”. Contudo, a informação disponível é ainda escassa devido às diversas complexidades do tema. Este trabalho pretende contribuir para a definição de uma metodologia de abordagem experimental para estudar, de forma objectiva, as alterações funcionais que caracterizam a pele obesa. O presente estudo, transversal, incluiu 28 voluntárias, do sexo feminino, saudáveis, com idade média 23±5 anos de idade, após consentimento informado. Foi realizada uma única medição de caracterização das diversas funções cutâneas obtidas por meios não invasivos em condições controladas. As variáveis consideradas relevantes foram, a hidratação (superficial e profunda) a função de barreira e o comportamento biomecânico, medidos em 4 áreas anatómicas distintas. Através do SPSS (v 20.0) realizámos uma análise estatística univariada com cálculo de medidas de tendência central e de dispersão. Recorremos aos testes de Pearson e de Spearman, para as variáveis que seguiam, ou não, uma distribuição normal, respectivamente, adoptando um grau de confiança de 95% . Os resultados permitem propor uma metodologia para o estudo da pele, aplicável ao doente obeso, incluindo a escolha das áreas anatómicas e das variáveis adequadas ao objetivo pretendido.
Bibliographic data
Translated title: | Desenvolvimento de um método in vivo para melhor compreender a pele do obeso |
---|---|
Journal Title: | Jornal de Investigação Biomédica e Biofarmacêutica |
First author: | Liliana Tavares |
Other Authors: | Lídia Palma; Mª Angélica Almeida; Mª Julia Bujan; Luís Monteiro Rodrigues |
Palabras clave: | |
Traslated Keywords: | |
Language: | English Portuguese |
Get full text: | http://www.alies.pt/BBR%20Editions/Vol-9-1-2012/Article7_9n1.pdf |
Resource type: | Journal Article |
Source: | Jornal de Investigação Biomédica e Biofarmacêutica; Vol 9, No 1 (Year 2012). |
DOI: | http://dx.doi.org/10.19277/bbr.19.1.30 |
Publisher: | Associação Lusófona para o Desenvolvimento da Investigação e Ensino em Ciências da Saúde |
Usage rights: | Reconocimiento - NoComercial (by-nc) |
Categories: | Life Sciences --> Biochemistry --AMP-- Molecular Biology Health Sciences --> Pharmacology --AMP-- Pharmacy Health Sciences, Life Sciences --> Physiology |
Statistical data
- Views
- Consultations
- Citation style
- Share
- Export record
- Favourites
Bibliography: | [1] Formiguera X, Cantón A. Obesity: epidemiology and clinical aspects. Best Practice & Research Clinical Gastroenterology Vol. 18, No. 6, pp. 1125–1146, 2004 [2] Yosipovich G, De Vore A, Dawn A. Obesity and skin: Skin physiology and skin manifestations of Obesity. J Am Acad Dermatol, 2007;6: 901-16. [3] Nino M, Franzese A, Ruggiero Perrino N, Balato N. The Effect of Obesity on Skin Disease and Epidermal Permeability Barrier Status in Children. Pediatr Dermatol. 2012 Apr 4. [4] Guida B, Nino M, Perrino NR, Laccetti R, Trio R, Labella S, Balato N, The impact of obesity on skin disease and epidermal permeability barrier status. J Eur Acad Dermatol Venereol. 2010 Feb;24(2):191-5. Epub 2009 Nov 19. [5] Löffler H, Aramaki JU, Effendy I. The influence of body mass index on skin susceptibility to sodium lauryl sulphate. Skin Res Technol. 2002 Feb;8(1):19-22 [6] Matsuzawa Y, Shimomura I, Nakamura T, Keno Y, Kotani K, Tokunaga K. Pathophysiology and pathogenesis of visceral fat obesity. Obes Res. 1995 Sep;3 Suppl 2:187S-194S. [7] Sebastian JL. Bariatric surgery and work-up of the massive weight loss patient. Clin Plast Surg. 2008 Jan; 35 (1):11-26 [8] Shermak MA, Rotellini-Coltvet LA, Chang D. Seroma development following body contouringsurgery for massive wheight loss: patient risk factos and treatment srtategies. Plast Reconstr Surg. 2008, Jul-, 122(1): 280-8 [9] WHO expert consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. The Lancet, 2004; 157-163. [10] WHO, Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. WHO Technical Report Series 854. Geneva: World Health Organization, 1995 [11] Garrow JS, Welster J. Quetelet's index (W/H2) as a measure of fatness. Int J Obes 1985; 9: 147–153. [12] República, Lei 46/2004 de 19 de Agosto. [13] EUROPEAN DIRECIVE 2001/20/EC on the approximation of the laws, regulations and administrative provisions of the Member State relating to the implementation of good clinical practice in the conduct. Of clinical trials on medicinal products for human use, Off J Europ Communities, L121/34-44, 2001. [14] Note for Guidance on Good Clinical Practice, ICH E6GCP96, EMEA, 2002: 1-55. [15] World Medical Association declaration of Helsinky. Ethical Principles for Medical Research Involving Human subjects, amended until 2004 Rogiers V [16] ; EEMCO Group. EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences. Skin Pharmacol Appl Skin Physiol 2001;14 (2):117-28. [17] Piérard GE, EEMCO guidance to the in vivo assessment of tensile functional properties of the skin. Part 1: relevance to the structures and ageing of the skin and subcutaneous tissues. Skin Pharmacol Appl Skin Physiol. 1999;12(6):352-62 [18] Rodrigues L; EEMCO, EEMCO guidance to the in vivo assessment of tensile functional properties of the skin. Part 2: instrumentation and test modes. Skin Pharmacol Appl Skin Physiol. 2001;14(1):52-67. [19] Darlenski R, Sassning S, Tsankov N, Fluhr JW. Non-invasive in vivo methods for investigation of the skin barrier physical properties. Eur J Pharm and Biopharm. 2009, 72:295-303 |
---|